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Foot-and-mouth disease: host range and pathogenesis

S Alexandersen1, N Mowat

  • 1Pirbright Laboratory, Institute for Animal Health, Ash Road, Pirbright, Woking, Surrey, GU24 ONF, UK. soren.alexandersen@bbsrc.ac.uk

Current Topics in Microbiology and Immunology
|January 15, 2005
PubMed

Insights

This review examines the host range of foot-and-mouth disease (FMD) in natural and experimental settings. It details infection routes, incubation, and clinical signs, advancing understanding of FMD pathogenesis.

Area of Science:

  • Veterinary Virology
  • Infectious Diseases
  • Pathogenesis Studies

Background:

  • Foot-and-mouth disease (FMD) is a highly contagious viral disease affecting cloven-hoofed animals.
  • Understanding FMD's host range is crucial for disease control and prevention strategies.

Purpose of the Study:

  • To comprehensively review the host range of FMD virus (FMDV).
  • To describe routes of infection, incubation periods, and clinical/pathological manifestations.
  • To correlate findings with advancements in FMD pathogenesis.

Main Methods:

  • Literature review of natural and experimental FMD infections.
  • Analysis of epidemiological data and experimental study results.
  • Synthesis of information on viral entry, spread, and host response.

Main Results:

  • Detailed description of susceptible species and variations in disease presentation.
  • Characterization of primary infection sites and systemic dissemination pathways.
  • Identification of key factors influencing incubation periods and disease severity.

Conclusions:

  • FMDV exhibits a broad host range, with variations influenced by viral strain and host factors.
  • Understanding infection dynamics is key to predicting and managing FMD outbreaks.
  • Continued research into FMD pathogenesis improves diagnostic and control measures.

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