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The structure of foot-and-mouth disease virus

E E Fry1, D I Stuart, D J Rowlands

  • 1Division of Structural Biology, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN, UK.

Current Topics in Microbiology and Immunology
|January 15, 2005
PubMed

Insights

Structural studies reveal foot-and-mouth disease virus (FMDV) capsid and key proteins. This knowledge aids understanding of FMDV

Area of Science:

  • Virology
  • Structural Biology
  • Immunology

Background:

  • Foot-and-mouth disease virus (FMDV) structural studies have primarily examined the mature viral particle.
  • Atomic resolution images of the FMDV protein capsid are available for multiple sero- and sub-types.
  • Structures of immunogenic surface loops and receptor complexes are also documented.

Purpose of the Study:

  • To review current structural knowledge of FMDV.
  • To assess the impact of structural data on understanding the FMDV life cycle.
  • To identify future structural targets for FMDV research.

Main Methods:

  • Review of existing structural data from various studies.
  • Analysis of atomic resolution images of viral components.
  • Integration of structural findings with knowledge of FMDV life cycle processes.

Main Results:

  • Comprehensive structural information exists for the FMDV capsid and surface loops.
  • Structural data illuminates interactions with host cell receptors (GAG).
  • Structures of some non-structural proteins provide insights into viral replication.

Conclusions:

  • Current structural knowledge provides a foundation for understanding FMDV infection.
  • Structural insights are crucial for comprehending immune evasion and inactivation mechanisms.
  • Further structural studies are needed to target key viral components and processes.

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