Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Rat hippocampus and primary immune response.

R Sheela Devi1, R M Anand Sivaprakash, A Namasivayam

  • 1Department of Physiology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, Taramani, Chennai-600 113.

Indian Journal of Physiology and Pharmacology
|January 15, 2005
PubMed
Summary

The hippocampus is crucial for a healthy immune response. Lesioning the dorsolateral hippocampus (DLH) or ventral hippocampal formation (VHF) in rats impaired their antibody production following an immune challenge.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

EFFECT OF OCIMUM SANCTUM LINN ON CHANGES IN LEUCOCYTES OF ALBINO RATS INDUCED BY ACUTE NOISE STRESS.

Indian journal of physiology and pharmacology·2016
Same author

Behavioral analysis after sciatic nerve compression in albino rats.

Annals of neurosciences·2014
Same author

Locomotor behavior of bonnet monkeys after spinal contusion injury: footprint study.

Synapse (New York, N.Y.)·2012
Same author

Effect of noise stress on free radical scavenging enzymes in brain.

Environmental toxicology and pharmacology·2011
Same author

Finger pulse volume in patients with panic attacks.

Indian journal of psychiatry·2011
Same author

Finger - pulse volume during co(2) induced panic States.

Indian journal of psychiatry·2011

Area of Science:

  • Neuroimmunology
  • Behavioral Neuroscience
  • Immunology

Background:

  • The hippocampus influences neurotransmitter levels during immune challenges.
  • Hippocampal function is linked to immune system modulation.
  • Electrolytic lesions in the hippocampus may disrupt immune responses.

Purpose of the Study:

  • To investigate the impact of dorsolateral hippocampus (DLH) and ventral hippocampal formation (VHF) lesions on humoral immunity.
  • To assess the role of the hippocampus in antibody production after an immune challenge.

Main Methods:

  • Electrolytic lesions were induced in the DLH and VHF of albino rats.
  • Humoral immunity was assessed by monitoring haemagglutination titre, IgM, and IgG levels.
  • Animals were immunized with sheep red blood cells (SRBC) and challenged with antigen.

Related Experiment Videos

Main Results:

  • Lesioned animals exhibited lower circulating antibody titres compared to controls.
  • Both DLH and VHF lesions significantly reduced IgM levels in immunized rats.
  • VHF lesions specifically led to a significant decrease in IgG levels post-immunization.

Conclusions:

  • An intact hippocampal region is essential for normal primary humoral immune response in rats.
  • The ventral hippocampal formation (VHF) may play a role in the secondary immune response, as suggested by IgG level alterations.