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Related Experiment Videos

The normal menopause transition.

S M McKinlay1, D J Brambilla, J G Posner

  • 1New England Research Institute, Watertown, Massachusetts 02172.

Maturitas
|January 1, 1992
PubMed
Summary
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Smoking significantly impacts menopause, leading to earlier onset and shorter duration. This study analyzed menopause transitions in mid-aged women, revealing smoking as a key factor influencing timing and symptoms.

Area of Science:

  • Reproductive Endocrinology
  • Epidemiology
  • Women's Health

Background:

  • The menopausal transition is a critical period in mid-aged women's lives.
  • Understanding factors influencing menopause onset and duration is essential for women's health.
  • Previous studies lacked comprehensive data on the natural menopause transition.

Purpose of the Study:

  • To define natural menopause transitions and their timing.
  • To identify factors affecting menopause transitions.
  • To characterize symptoms associated with menopause.

Main Methods:

  • Prospective cohort study (Massachusetts Women's Health Study) of 2570 women aged 45-55.
  • 5 years of follow-up with 6 telephone contacts at 9-month intervals.

Related Experiment Videos

  • Analysis of baseline survey data and longitudinal follow-up data.

    • Main Results:

    • Median age at natural menopause was 51.3 years.
    • Current smokers experienced menopause 1.8 years earlier than non-smokers.
    • Perimenopause began at a median age of 47.5 years, with smokers having earlier and shorter transitions (nearly 4 years duration).

    Conclusions:

    • Smoking is a significant factor influencing the timing and duration of menopause.
    • Longer perimenopause transitions correlate with higher physician consultation rates.
    • Symptom reporting varies across menopause stages, increasing in perimenopause and decreasing in postmenopause.