Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Angiogenesis in neuroblastoma.

Domenico Ribatti1, Danilo Marimpietri, Fabio Pastorino

  • 1Department of Human Anatomy and Histology, University of Bari Medical School, Piazza Giulio Cesare, 11, Policlinico, I-70124 Bari, Italy. ribatti@anatomia.uniba.it

Annals of the New York Academy of Sciences
|January 15, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Real-world evidence on infection risk in multiple myeloma treated with BiTEs and CAR-T cells: a meta-analysis.

Experimental hematology & oncology·2026
Same author

Eosinophil-linked pulmonary circulation in EGPA Improves under anti-IL-5/R therapy: A longitudinal study.

European journal of internal medicine·2026
Same author

Inborn errors of immunity: a structured model for paediatric-to-adult transition of care.

Frontiers in immunology·2026
Same author

Navigating primary and secondary immunodeficiency intersections: how to find IEI hidden within SID.

Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology·2026
Same author

Efficacy of belimumab in patients with SLE and haematological manifestations: retrospective analysis from the BeRLiSS 2.0 cohort.

Lupus science & medicine·2026
Same author

Real-world incidence of severe infections in multiple myeloma patients receiving bispecific antibodies: a meta-analysis.

Annals of hematology·2026

Angiogenesis, the formation of new blood vessels, is crucial in neuroblastoma tumor growth and spread. Inhibiting this process may offer a new treatment strategy for this childhood cancer.

Area of Science:

  • Oncology
  • Developmental Biology
  • Pathology

Background:

  • Angiogenesis is essential for tumor growth, marking the transition from avascular to vascular phases.
  • In neuroblastoma, a common childhood cancer, angiogenesis significantly influences tumor characteristics and progression.
  • The angiogenic balance involves stimulators like VEGF and FGF-2, and inhibitors such as TIMPs, with MMP-2 and -9 implicated in advanced stages.

Purpose of the Study:

  • To explore the role of angiogenesis in neuroblastoma.
  • To investigate the correlation between tumor vascularity and clinical features.
  • To assess the potential of anti-angiogenic strategies in neuroblastoma treatment.

Main Methods:

  • Analysis of angiogenic factors (VEGF, FGF-2, TIMPs, MMPs) in neuroblastoma tumors.

Related Experiment Videos

  • Correlation of tumor vascularity with clinical parameters (disease stage, MYCN amplification, histology, outcome).
  • Review of preclinical evidence for anti-angiogenic therapies in neuroblastoma.

    • Main Results:

    • High tumor vascularity in neuroblastoma is linked to disseminated disease, MYCN amplification, unfavorable histology, and poor prognosis.
    • Low tumor vascularity is associated with localized disease and favorable histology.
    • Increased MMP-2 and -9 production is observed in advanced neuroblastoma, promoting matrix degradation and dissemination.

    Conclusions:

    • Angiogenesis plays a complex and significant role in neuroblastoma progression and outcome.
    • Tumor vascularity serves as a prognostic indicator in neuroblastoma.
    • Targeting angiogenesis represents a promising therapeutic avenue for neuroblastoma, potentially inhibiting tumor cell dissemination and metastasis.