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Updated: Aug 20, 2026

Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)
04:56

Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)

Published on: August 4, 2023

Performance and prognostic importance of a new clinical and laboratory scoring system for identifying non-overt

Cheng Hock Toh1, Colin Downey

  • 1Roald Dahl Haemostasis & Thrombosis Centre, Royal Liverpool University Hospital, Prescot Street, Liverpool L7 8XP, UK. toh@liverpool.ac.uk

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
|January 15, 2005
PubMed

Insights

A new scoring template for diagnosing non-overt disseminated intravascular coagulation (DIC) is feasible and prognostic. A score of 5 or greater indicates non-overt DIC and is associated with significantly higher mortality rates.

Area of Science:

  • Critical Care Medicine
  • Hematology
  • Clinical Diagnostics

Background:

  • A template for diagnosing non-overt disseminated intravascular coagulation (DIC) requires validation.
  • Assessing the prognostic significance of this scoring template is crucial for clinical application.

Purpose of the Study:

  • To evaluate the feasibility of a non-overt DIC scoring template.
  • To determine the prognostic significance of the derived scores for overt DIC and mortality.

Main Methods:

  • A 2-month feasibility study followed by a 12-month prospective study in an intensive care unit.
  • Consecutive patients were assessed using the non-overt DIC scoring template.
  • Outcome measures included overt DIC development and 28-day mortality.

Main Results:

  • The scoring template demonstrated practical feasibility.
  • Scores of 5 or greater were associated with mortality in the initial study.
  • In the prospective study, mortality was 29% for scores <5 and 78% for scores ≥5, with similar mortality for overt DIC.

Conclusions:

  • The non-overt DIC scoring template is workable and prognostically relevant.
  • A score of 5 or greater is recommended for diagnosing non-overt DIC.
  • This diagnostic tool aids in identifying high-risk patients for timely intervention.

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