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Updated: Aug 6, 2026

The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis
Published on: August 11, 2008
Normal D-dimer levels in patients with latent tuberculosis infection
D Shitrit1, G Izbicki, A Bar-Gil Shitrit
1Pulmonary Institute, Rabin Medical Center, Beilinson Campus, Petah Tiqwa 49100, Israel.
Latent tuberculosis infection (LTI) does not appear to cause a hypercoagulable state, as indicated by normal D-dimer levels in patients with suspected LTI. This suggests low-level inflammation from LTI does not impact blood coagulation.
Area of Science:
- Pulmonary Medicine
- Hematology
- Infectious Diseases
Background:
- Acute pulmonary tuberculosis is linked to a hypercoagulable state.
- Limited data exist on the coagulation status in latent tuberculosis infection (LTI).
Purpose of the Study:
- To investigate the coagulation state in patients with suspected LTI.
- To determine if LTI is associated with a hypercoagulable state.
Main Methods:
- Prospective observational study of 84 patients with suspected LTI undergoing purified protein derivative (PPD) testing.
- D-dimer levels, a marker of coagulation, were measured using the quantitative Miniquant test.
- D-dimer values were correlated with PPD status and clinical parameters.
Main Results:
- No significant difference in D-dimer levels was observed between LTI-positive (n=57) and LTI-negative (n=27) groups.
- D-dimer levels were not significantly correlated with PPD status, age, or occupation.
- All measured D-dimer levels were within the normal range.
Conclusions:
- Latent tuberculosis infection does not appear to induce a hypercoagulable state.
- Low-level inflammation associated with LTI does not significantly affect blood coagulation markers like D-dimer.
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