Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Functional connectivity in an fMRI working memory task in high-functioning autism.

Hideya Koshino1, Patricia A Carpenter, Nancy J Minshew

  • 1Center for Cognitive Brain Imaging, Carnegie Mellon University, Pittsburgh, PA 15213, USA. hkoshino@csusb.edu

Neuroimage
|January 18, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neural Representations of Death-Related Concepts Identify Conceptual Alteration of Self in Suicidal Youth.

Human brain mapping·2026
Same author

Inference complexity and the logic bias effect in conditional reasoning.

Quarterly journal of experimental psychology (2006)·2025
Same author

The neural and cognitive basis of expository text comprehension.

NPJ science of learning·2024
Same author

Cooperation and competition between the default mode network and frontal parietal network in the elderly.

Frontiers in psychology·2023
Same author

Rapid neuroplasticity changes and response to intravenous ketamine: a randomized controlled trial in treatment-resistant depression.

Translational psychiatry·2023
Same author

Retraction Note: Machine learning of neural representations of suicide and emotion concepts identifies suicidal youth.

Nature human behaviour·2023
Same journal

Spatial frequency channels implement a mental ruler in spatial vision.

NeuroImage·2026
Same journal

Exploring the Link Between Intravoxel Incoherent Motion Measured Brain Diffusivity During Wakefulness and Sleep Macrostructure in the Elderly.

NeuroImage·2026
Same journal

Closed-loop adaptation of transcranial magnetic stimulation intensity with electroencephalography feedback.

NeuroImage·2026
Same journal

Volumetric postmortem MRI of the medial temporal lobe in Alzheimer's disease and related disorders: methodological advances and implications for in vivo biomarker development.

NeuroImage·2026
Same journal

Neural responses to equity and inequity when receiving vicarious rewards for self and charity during adolescence.

NeuroImage·2026
Same journal

Cognitive Strategy-based neuromodulation optimizes neural communication to improve working memory.

NeuroImage·2026
See all related articles

Adults with high-functioning autism and controls showed similar working memory performance. However, brain imaging revealed distinct neural strategies, with autistic adults potentially using visual coding and controls using verbal coding.

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Autism Spectrum Disorder Research

Background:

  • Working memory is crucial for cognitive function.
  • Understanding neural differences in autism spectrum disorder (ASD) is vital.
  • Previous research suggests atypical cognitive processing in ASD.

Purpose of the Study:

  • To investigate brain activation patterns during a working memory task in adults with high-functioning autism compared to neurotypical controls.
  • To explore differences in neural strategies employed by these groups.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was used.
  • Participants included adults with high-functioning autism and age-matched controls.
  • An n-back task involving letter stimuli was administered.

Related Experiment Videos

Main Results:

  • Behavioral performance was comparable between groups.
  • fMRI revealed distinct activation patterns: controls showed left-dominant parietal activation, while the autism group exhibited right-lateralized prefrontal and parietal activation.
  • The autism group showed increased activation in posterior regions (inferior temporal, occipital).
  • Functional connectivity analysis indicated different hemispheric correlations between groups.

Conclusions:

  • Adults with high-functioning autism and controls may utilize different cognitive strategies (visual vs. verbal coding) for working memory.
  • Distinct patterns of brain activation and functional connectivity are associated with high-functioning autism during this task.