Related Experiment Video
Updated: Aug 20, 2026
Assessment of Zebrafish Lens Nucleus Localization and Sutural Integrity
Published on: May 6, 2019
Ultrastructure of internal limiting membrane in myopic foveoschisis
Hajime Bando1, Yasushi Ikuno, Jun-Sub Choi
1Department of Ophthalmology, Graduate School of Medicine, Osaka University, Osaka, Japan. bando@ophthal.med.osaka-u.ac.jp
Purpose:
To reveal the pathogenesis of myopic foveoschisis (MF).
Design:
Clinicopathological report.
Methods:
Internal limiting membranes (ILMs) were collected from ten patients with MF and five patients with idiopathic macular hole (IMH) as a control. Samples were subjected to transmission electron microscopic study. Characteristics of the ILM were compared between the two groups.
Results:
Collagen fiber and cell debris were identified on the inner surface of ILM in seven eyes (70%) with MF, significantly more (P < .05) than found in IMH subjects (0%). More fibrous glial cells were likely to be found on the inner surface of ILM. No significant difference in fibroblast-like cell adhesion was observed.
Conclusions:
Collagen fiber and cellular component are suggested to play an important role in developing MF. ILM peeling may be essential for vitrectomy for MF.
Related Concept Videos
01:20Anatomy of the Eyeball
01:16Focusing of Light in the Eye
01:25Glaucoma: Overview