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Matrix metalloproteinases in ascending aortic aneurysms: bicuspid versus trileaflet aortic valves

Scott A LeMaire1, Xinwen Wang, Jonathan A Wilks

  • 1Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine and The Methodist DeBakey Heart Center, Houston, Texas, USA. slemaire@bcm.tmc.edu

The Journal of Surgical Research
|January 18, 2005
PubMed
Abstract

Insights

Ascending aortic aneurysms show altered matrix metalloproteinase (MMP) expression. Differences in MMP patterns and inflammation exist between bicuspid (BAV) and trileaflet (TAV) aortic valve aneurysms.

Area of Science:

  • Cardiovascular Research
  • Molecular Biology
  • Aortic Disease

Background:

  • Abnormal matrix metalloproteinase (MMP) and tissue inhibitor of metalloproteinase (TIMP) expression is implicated in abdominal aortic aneurysms.
  • MMP-2 and MMP-9 may play a role in thoracic aortic disease.

Purpose of the Study:

  • To determine if ascending aortic aneurysms are associated with increased MMP expression.
  • To investigate differences in aortic inflammation and MMP expression between congenital bicuspid aortic valves (BAVs) and trileaflet aortic valves (TAVs).

Main Methods:

  • Ascending aortic aneurysm samples from 29 patients (14 BAV, 15 TAV) and 14 controls were analyzed.
  • Histology, immunohistochemistry, and ELISA were used to assess elastin degradation, inflammation, and MMP/TIMP levels.

Main Results:

  • TAV aneurysms showed inflammation, high CD68, reduced elastin, and increased MMP-9.
  • BAV aneurysms had less inflammation, preserved elastin, normal MMP-9, and elevated MMP-2.
  • TIMP-1 and TIMP-2 levels were similar across groups.

Conclusions:

  • Ascending aortic aneurysms are associated with increased MMP expression.
  • Distinct patterns of MMP expression and inflammation differentiate BAV and TAV aneurysms.
  • Further research is needed to understand the molecular mechanisms of different thoracic aortic aneurysms.

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