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Adhesion remodeling underlying tissue morphogenesis.

Thomas Lecuit1

  • 1Laboratoire de Génétique et de Physiologie du Développement, UMR 6545 CNRS-Université de la Méditerranée, Institut de Biologie du Développement de Marseille, Campus de Luminy case 907, 13288 Marseille cedex 09, France. lecuit@ibdm.univ-mrs.fr

Trends in Cell Biology
|January 18, 2005
PubMed
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Epithelial cells use cell adhesion molecules at adherens junctions to maintain structure but control movement during development. Regulated remodeling of these junctions is key for cell shape, contact, and patterned movements like intercalation.

Area of Science:

  • Cell biology
  • Developmental biology
  • Biophysics

Background:

  • Cell-adhesion molecules at adherens junctions (AJs) are crucial for epithelial cell polarity and structure.
  • These molecules, particularly cadherins, regulate cell shape and intercellular adhesion.
  • Epithelial morphogenesis involves dynamic remodeling of cell contacts and shapes.

Purpose of the Study:

  • To explore the role of regulated cell adhesion in epithelial morphogenesis.
  • To understand how adherens junction remodeling influences cell shape and movement.
  • To highlight the importance of studying developing organisms for insights into cell adhesion.

Main Methods:

  • Observational studies of epithelial development.
  • Analysis of cell-cell adhesion dynamics.

Related Experiment Videos

  • Investigation of cadherin regulation in vivo.

    • Main Results:

    • Adherens junction remodeling is spatially and temporally controlled during epithelial morphogenesis.
    • Polarized remodeling of AJs is essential for patterned cell movements, including cell intercalation.
    • Cell shape is influenced by the regulation of adhesion between cell groups.

    Conclusions:

    • Regulated cell adhesion is fundamental to epithelial architecture and morphogenesis.
    • Understanding adherens junction dynamics provides insights into tissue development and cell movement.
    • Developing organisms offer valuable models for studying regulated adhesion processes.