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Bethanecol chloride for treatment of clomipramine-induced orgasmic dysfunction in males
Márcio Bernik1, Antonio Hélio Guerra Vieira, Paula Villela Nunes
1Anxiety Clinic, Department of Psychiatry, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, São Paulo, SP, Brazil. amban@amban.org.br
Purpose:
To investigate whether bethanecol chloride may be an alternative for the clinical management of clomipramine-induced orgasmic dysfunction, reported to occur in up to 96% of male users.
Methods:
In this study, 12 fully remitted panic disorder patients, complaining of severe clomipramine-induced ejaculatory delay, were randomly assigned to either bethanecol chloride tablets (20 mg, as needed) or placebo in a randomized, double-blind, placebo-controlled, two-period crossover study. A visual analog scale was used to assess severity of the orgasmic dysfunction.
Results:
A clear improvement was observed in the active treatment period. No placebo or carry-over effects were observed.
Conclusion:
These findings suggest that bethanecol chloride given 45 minutes before sexual intercourse may be useful for clomipramine-induced orgasmic dysfunction in males.
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