Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

alpha-Gustducin immunoreactivity in the airways.

Flavia Merigo1, Donatella Benati, Marco Tizzano

  • 1Department of Morphological-Biomedical Sciences, Human Anatomy and Histology Section, University of Verona, Verona, Italy.

Cell and Tissue Research
|January 18, 2005
PubMed
Summary

Solitary cells in rat airways express alpha-gustducin, a marker for chemoreceptive cells. These cells possess specialized features, indicating a distinct chemosensory cell type within the respiratory system.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In Vitro Evaluation of Mechanical Fat Processing Devices: Impact on Adipocytes and Adipose-Derived Stem Cells.

Stem cells international·2026
Same author

Comorbidities in lipedema: toward a systemic perspective - a narrative review.

Clinical and experimental medicine·2026
Same author

Role of hypertrophic adipocytes, collagen VI, and CD38 in adipose tissue fibrosis in obesity.

Scientific reports·2026
Same author

The structure and function of taste G protein-coupled receptors and their implications in diseases.

International journal of oral science·2026
Same author

Choline acetyltransferase as a marker for Merkel cells in mucosal and skin tissues.

Journal of oral biosciences·2026
Same author

The Liquid Genioplasty: Different Techniques Compared.

Aesthetic plastic surgery·2026

Area of Science:

  • Respiratory biology
  • Cell biology
  • Neuroscience

Background:

  • Alpha-gustducin is a known marker for chemoreceptive cells.
  • The presence and function of chemoreceptive cells in the airway epithelium are not fully understood.

Purpose of the Study:

  • To investigate the immunohistochemical localization of alpha-gustducin in rat airway epithelium.
  • To determine if alpha-gustducin-immunoreactive cells constitute a distinct cell subset in rat airways.

Main Methods:

  • Light and electron microscopy were used to examine alpha-gustducin localization.
  • Double-label immunocytochemistry was performed using antibodies for protein gene product (PGP) 9.5 and phospholipase C beta2 (PLCbeta2).

Main Results:

Related Experiment Videos

  • Alpha-gustducin immunoreactivity was observed in solitary, flask-shaped or pear-shaped cells with apical microvilli, characteristic of chemoreceptor cells.
  • Immunostaining was concentrated in the apical process and basolateral cell surface.
  • A subset of alpha-gustducin-immunoreactive cells co-expressed PGP 9.5 or PLCbeta2, suggesting heterogeneity and specialized functions.

    • Conclusions:

    • Solitary alpha-gustducin-immunoreactive cells are present throughout the rat airways.
    • These cells exhibit morphological and immunohistochemical characteristics of chemoreceptor cells, representing a specialized cell type.