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Related Experiment Videos

Nuclear receptor coregulators are new players in nervous system development and function.

Eijun Nishihara1, Bert W O'Malley, Jianming Xu

  • 1Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.

Molecular Neurobiology
|January 19, 2005
PubMed
Summary

Nuclear receptors (NRs) regulate nervous system development and function via coactivators and corepressors. These proteins fine-tune gene expression, impacting numerous physiological processes in the brain.

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Endocrinology

Background:

  • Steroid/thyroid hormones and nuclear receptors (NRs) are crucial for nervous system development and function.
  • NRs regulate gene expression through transcriptional intermediary coregulators: coactivators and corepressors.

Purpose of the Study:

  • To summarize current knowledge on the molecular mechanisms, expression patterns, and biological functions of NR coactivators and corepressors in the nervous system.
  • To highlight the broad functional spectrum of these coregulators.

Main Methods:

  • Review of recent scientific literature.
  • Synthesis of findings on NR coactivator and corepressor mechanisms and functions.

Main Results:

Related Experiment Videos

  • Detailed overview of key NR coactivators (e.g., p160 family, CBP, p300, BRG1) and corepressors (e.g., NCoR, SMRT).
  • Elucidation of how these coregulators modulate NR transcriptional activity and target gene expression.
  • Evidence for diverse roles in nervous system physiology.

    • Conclusions:

    • NR coactivators and corepressors possess a broader functional range than previously understood.
    • These coregulators are integral to various physiological aspects of nervous system development and function.