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Published on: July 4, 2015
Redox signaling by ionizing radiation in mouse liver
Jeung Hee An1, Jiyoung Kim, Jinsil Seong
1Department of Radiation Oncology, Brain Korea 21 Project for Medical Science, Yonsei University Medical College, Shinchon-dong 134, Seodamun-Ku, Seoul 120-752, Korea.
Annals of the New York Academy of Sciences
|January 22, 2005
Summary
Radiation therapy for liver tumors reveals a complex cellular response. Ionizing radiation alters protein expression, activating a protective antioxidant system alongside cytotoxic effects.
Area of Science:
- Proteomics and Molecular Biology
- Hepatology and Radiation Oncology
Background:
- Radiation treatment for hepatic tumors is gaining renewed interest.
- Understanding the liver's cellular response to radiation is crucial.
Purpose of the Study:
- To identify signaling proteins involved in liver tissue's response to ionizing radiation.
- To characterize the proteomic changes following radiation exposure.
Main Methods:
- Utilized a proteomics approach to analyze cellular responses of liver tissue.
- Quantified protein expression changes after ionizing radiation exposure.
Main Results:
- Detected approximately 800 protein spots, with 28 showing significant quantitative alterations.
- Altered proteins were associated with reactive oxygen species (ROS) metabolism, metabolic pathways, and G-type proteins.
- Increased expression of ROS metabolism proteins (cytochrome c, glutathione S-transferase Pi, NADH dehydrogenase, peroxiredoxin VI) observed post-radiation.
Conclusions:
- Radiation exposure in liver tissue triggers significant proteomic alterations.
- The liver activates a radioprotective antioxidant system in response to radiation-induced damage.
