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Celiac disease with various presentations

Tumay Doganci1, Serap Bozkurt

  • 1Department of Gastroenterology, Children's Hospital, Ankara, Turkey. levdog@gata.edu.tr

Pediatrics International : Official Journal of the Japan Pediatric Society
|January 22, 2005
PubMed

Insights

Celiac disease (CD) in children presents varied symptoms. Anemia and short stature are common in pediatric CD cases, with short stature linked to lower vitamin B12 levels.

Area of Science:

  • Pediatric Gastroenterology
  • Immunology
  • Nutritional Science

Background:

  • Celiac disease (CD) exhibits a broad clinical spectrum, ranging from malabsorption to extra-intestinal manifestations.
  • This study evaluated 45 children diagnosed with CD, focusing on common presentations like chronic diarrhea, anemia, and short stature.

Purpose of the Study:

  • To identify common parameters across diverse presentations of celiac disease in children.
  • To investigate the relationship between specific CD symptoms and clinical findings.

Main Methods:

  • Comparison of basic anthropometric, biochemical, and hematological parameters in children with various CD presentations.
  • Analysis of clinical data from 45 pediatric celiac disease cases.

Main Results:

  • Children with CD and chronic diarrhea were observed to be younger.
  • No significant difference in hemoglobin levels was found in children presenting with anemia.
  • Children with CD and short stature showed significantly lower serum vitamin B12, reduced height standard deviation scores, delayed bone age, and lower alkaline phosphatase levels.

Conclusions:

  • Pediatric celiac disease, particularly in infants with chronic diarrhea, may not always involve generalized malabsorption.
  • Anemia and short stature are frequent findings in celiac disease, irrespective of whether they are the primary presenting symptoms.
  • Children with celiac disease presenting with short stature may exhibit lower vitamin B12 levels compared to other presentations.
Abstract

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