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Updated: Jul 31, 2026
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An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells
Published on: September 12, 2019
Lymph node metastases in low-grade endometrial stromal sarcoma
J Riopel1, M Plante, M-C Renaud
1Department of Pathology, Centre Hospitalier Universitaire de Québec (CHUQ)-Pavillon L'Hôtel-Dieu de Québec, 11 Côte du Palais, Québec, Québec, Canada G1R 2J6.
Gynecologic Oncology
|January 22, 2005
Summary
Lymph node metastasis is more common in low-grade endometrial stromal sarcoma than previously thought. This study highlights the need for thorough lymph node sampling in these patients to understand the frequency and impact of metastases.
Area of Science:
- Gynecologic Oncology
- Pathology
Background:
- Low-grade endometrial stromal sarcoma (LG-ESS) is a rare uterine malignancy.
- The extent of lymphatic dissemination in LG-ESS is not well-established.
Purpose of the Study:
- To investigate the incidence of lymph node involvement in patients diagnosed with LG-ESS.
- To review the experience with lymphatic spread in LG-ESS.
Main Methods:
- Retrospective review of pathology and gynecologic oncology records.
- Inclusion criteria: LG-ESS or endolymphatic stromal myosis diagnosed before October 2003 with lymph node sampling.
- Analysis of lymph node status at initial surgery, staging, or recurrence.
Main Results:
- Fifteen patients with LG-ESS and lymph node sampling were identified.
- 33% (5 out of 15) of patients had lymph node metastases.
- Metastases were detected at initial hysterectomy, staging, or recurrence.
Conclusions:
- Lymph node involvement in LG-ESS appears to be higher than previously recognized.
- Increased lymph node sampling in LG-ESS patients is recommended.
- Further research with larger cohorts is needed to clarify the prognostic significance of lymph node metastases in LG-ESS.
