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Validation of 2001 Partin tables in Turkey: a multicenter study
Saadettin Yilmaz Eskicorapci1, Erdem Karabulut, Levent Türkeri
1Hacettepe Universitesi, Uroloji ABD, Sihhiye, 06120 Ankara, Turkey. seskicorabci@hotmail.com
European Urology
|January 22, 2005
Summary
Partin tables, used globally for prostate cancer staging, show reasonable predictive accuracy for Turkish patients. This study validates their use in Turkey for predicting pathological outcomes.
Area of Science:
- Urology
- Oncology
- Medical Statistics
Background:
- Partin tables, developed in the US, are widely used internationally for preoperative prostate cancer staging.
- The predictive accuracy of the 2001 Partin tables has not been extensively validated in diverse populations, including Turkey.
Purpose of the Study:
- To evaluate the validity and predictive accuracy of the 2001 Partin tables for staging prostate cancer in Turkish patients.
- To assess if Partin tables can reliably predict pathological outcomes in a Turkish cohort.
Main Methods:
- A multicenter study involving 1043 patients who underwent radical prostatectomy.
- Analysis of clinical data (serum PSA, clinical stage, biopsy Gleason score) and pathological findings.
- Receiver Operating Characteristics (ROC) analysis to compare Partin nomogram predictions with pathological outcomes.
Main Results:
- The study included 1043 patients with a median age of 60.
- Key findings included 43% clinical stage T1c, 23.4% Gleason score 2-4, and 39.6% serum PSA >10 ng/ml.
- Area Under Curve (AUC) values for organ-confined disease, seminal vesicle, and lymph node involvement were 0.665, 0.733, and 0.759, respectively.
Conclusions:
- Partin tables demonstrate reasonable predictive value for organ-confined disease, seminal vesicle, and lymph node involvement in Turkish patients.
- The 2001 Partin tables can be utilized with comparable accuracy in the Turkish population for prostate cancer staging.