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Phacoanaphylactic endophthalmitis.
1Georgetown University, Washington, D.C.
Survey of Ophthalmology
|March 11, 1992
Summary
Phacoanaphylactic endophthalmitis, a rare condition after lens injury, is now understood as altered tolerance to lens proteins, not rejection. This review discusses its features, management, and pathogenesis.
Area of Science:
- Ophthalmology
- Immunology
Background:
- Phacoanaphylactic endophthalmitis is a rare inflammatory eye condition following lens injury.
- Its incidence may be influenced by modern cataract surgery techniques and low-grade infections.
Purpose of the Study:
- To review the clinical and histopathologic features of phacoanaphylactic endophthalmitis.
- To discuss current controversies in its clinical management.
- To review recent evidence on the pathogenesis of this condition.
Main Methods:
- Review of clinical and histopathologic findings.
- Analysis of recent evidence on pathogenesis.
- Discussion of management controversies.
Main Results:
- Phacoanaphylactic endophthalmitis is characterized by altered tolerance to lens proteins.
- The previously held theory of lens protein rejection is now considered incorrect.
Conclusions:
- Understanding altered tolerance to lens proteins is key to phacoanaphylactic endophthalmitis.
- Further research into pathogenesis and standardized management is warranted.