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Updated: Aug 20, 2026

Methods for the Isolation, Culture, and Functional Characterization of Sinoatrial Node Myocytes from Adult Mice
Published on: October 23, 2016
In vitro effect of acetylcholine on function of sinoatrial node in rat heart
P V Sutyagin1, E E Kalinina, A S Pylaev
1Department of Morphology, Russian State Medical University, Moscow. charyeva@yandex.ru
Abstract:
Electrophysiological parameters of true pacemakers in the sinoatrial node of rat heart were recorded intracellularly using glass microelectrodes. In 11 of 13 experiments acetylcholine in increasing doses did not induce migration of the dominant pacemaker region, while in two cases its minor migration upstream the sinus node artery was observed.
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