Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 24, 2026

An Orthotopic Bladder Cancer Model for Gene Delivery Studies
07:48

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

Published on: December 2, 2013

Molecular markers in bladder cancer.

Syed A Hussain1, Nicholas D James

  • 1Cancer Research UK, Institute for Cancer Studies, University Hospital Birmingham, Biringham B15 2TT, UK.

Seminars in Radiation Oncology
|January 22, 2005
PubMed
Summary

Identifying molecular predictors for bladder cancer treatment response is crucial. Understanding apoptotic signals can personalize therapies and improve patient outcomes by refining current prognostic systems.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diagnosis and Staging of Patients with Prostate Cancer: Report from the 2025 Advanced Prostate Cancer Consensus Conference (APCCC) Diagnostics.

European urology·2026
Same author

Comprehensive genome-wide association study into multiple recurrence and progression risk in non-muscle invasive bladder cancer.

Cancer genetics·2026
Same author

Pro-inflammatory diet predicts poorer survival in bladder cancer: Results from the bladder cancer prognosis programme.

Clinical nutrition (Edinburgh, Scotland)·2026
Same author

Development of an extended version of GALEAS bladder: Detection of FGFR3 fusions in urine and associations between genomic alterations and gene expression.

Bladder cancer (Amsterdam, Netherlands)·2026
Same author

International Survey of Thromboprophylaxis Practices During Neoadjuvant Therapy for Muscle-Invasive Bladder Cancer.

Clinical genitourinary cancer·2026
Same author

The role of HAI-1 in urothelial bladder cancer: Tissue expression, ectodomain shedding and clinical outcomes.

Biochemistry and biophysics reports·2026

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Bladder cancer is a significant genitourinary malignancy with available molecular pathogenesis data.
  • Current treatment efficacy, particularly chemotherapy, is limited by the inability to induce apoptosis in tumor cells.
  • Refining prognostic information beyond TNM and grading systems is essential for improved patient outcomes.

Purpose of the Study:

  • To investigate molecular pathogenesis and genetic predictors for bladder cancer.
  • To identify novel tumor markers for clinical practice to enhance prognostic information.
  • To understand apoptotic signals and pro-survival pathways for personalized cancer therapies.

Main Methods:

  • Review of existing literature on molecular pathogenesis of bladder cancer.
  • Analysis of genetic predictors for disease natural history and treatment response.
  • Exploration of apoptotic pathways and their role in treatment efficacy.

Main Results:

  • Extensive information exists on molecular pathogenesis and genetic predictors in bladder cancer.
  • Apoptotic resistance limits the efficacy of current chemotherapy regimens.
  • Further research into molecular mechanisms is needed to develop predictive markers.

Conclusions:

  • Predictive markers based on molecular profiles will aid clinical decision-making in bladder cancer.
  • Understanding apoptosis is key to refining bladder cancer treatments and individualizing therapy.
  • Prospective clinical trials are imperative to identify tailored treatment strategies considering molecular heterogeneity.

More Related Videos

Cell-Free DNA Integrity Analysis in Urine Samples
07:58

Cell-Free DNA Integrity Analysis in Urine Samples

Published on: January 5, 2017

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors
05:19

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors

Published on: March 29, 2019

Related Experiment Videos

Last Updated: Jul 24, 2026

An Orthotopic Bladder Cancer Model for Gene Delivery Studies
07:48

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

Published on: December 2, 2013

Cell-Free DNA Integrity Analysis in Urine Samples
07:58

Cell-Free DNA Integrity Analysis in Urine Samples

Published on: January 5, 2017

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors
05:19

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors

Published on: March 29, 2019