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Initial experience with gamma knife surgery for endocrine ophthalmopathy
Julio C Antico1, Luis Crovetto, Eduardo Tenca
1Department of Stereotactic, Functional, and Gamma Knife Radiosurgery, FLENI Neurology Institute, Buenos Aires, Argentina. jantico@fleni.org.ar
Object:
The aim of this study was to evaluate both the effectiveness and safety of the treatment of endocrine ophthalmopathy with gamma knife surgery (GKS).
Methods:
Five patients were included in a prospective study designed to assess the results of GKS of endocrine ophthalmopathy secondary to Graves disease. All the patients completed a 2-year follow-up period. During this period, the patients were evaluated both clinically and by means of additional methods, including computerized tomography and magnetic resonance imaging studies. The minimum dose delivered to the 50% isodose line was 6.5 Gy in all the patients. In all cases, a clinical improvement was observed. The best effect was seen in symptom regression related to soft-tissue involvement. No treatment-related side effects were detected.
Conclusions:
In light of the results obtained the authors consider that GKS may be a safe and effective way to treat endocrine ophthalmopathy.
