Related Experiment Video
Updated: Jun 11, 2026
23:56
Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model
Published on: November 1, 2010
Chronic kidney disease: the global challenge.
A Meguid El Nahas1, Aminu K Bello
1Sheffield Kidney Institute, Sheffield Teaching Hospital NHS Foundation Trust, Northern General Hospital Campus, University of Sheffield, Sheffield S5 7AU, UK. el-nahas@sheffield.ac.uk
Lancet (London, England)
|January 25, 2005
Summary
Chronic kidney disease (CKD) is rising globally, necessitating a shift from treating end-stage renal disease (ESRD) to aggressive prevention. Early detection and intervention are crucial to manage this growing epidemic.
Area of Science:
- Nephrology
- Public Health
- Epidemiology
Background:
- Global prevalence of chronic kidney disease (CKD) is increasing, posing a significant public health challenge.
- End-stage renal disease (ESRD) requiring renal replacement therapy is becoming epidemic, straining healthcare resources worldwide.
- Current treatment focuses on ESRD, but a shift towards primary and secondary prevention is imperative.
Purpose of the Study:
- To examine CKD epidemiology globally, focusing on early detection and prevention strategies.
- To review risk factors, progression markers, and mechanisms of renal scarring.
- To provide strategic recommendations for global CKD prevention and management.
Main Methods:
- Epidemiological analysis of worldwide CKD data.
- Review of risk factors, progression markers, and pathomechanisms of renal scarring.
- Assessment of current interventions and evidence for slowing CKD progression.
Main Results:
- CKD prevalence is escalating globally, with significant economic implications.
- Effective primary and secondary prevention methods are feasible and necessary.
- Understanding renal scarring mechanisms informs potential interventions.
Conclusions:
- A global, concerted approach to CKD prevention is essential for both developed and developing countries.
- Shifting focus to early detection and aggressive prevention is critical to avert a global health catastrophe.
- Future research should prioritize interventions to slow CKD progression and manage economic impacts.
Related Concept Videos
01:20COPD: Pathogenesis and Clinical Features
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
01:29Chronic Obstructive Pulmonary Disease-V: Management
Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
Smoking Cessation
Smoking Cessation
01:25Chronic Kidney Disease I: Introduction
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
01:28Toxoplasmosis
Toxoplasmosis, a zoonotic disease caused by the protozoan Toxoplasma gondii, poses significant public health challenges globally due to its high seroprevalence and varied clinical manifestations. As an obligate intracellular parasite, T. gondii can infect all warm-blooded vertebrates, but felids are its only definitive hosts, shedding unsporulated oocysts into the environment. Humans typically acquire the infection through ingestion of tissue cysts in undercooked meat or oocysts from...
01:22American Trypanosomiasis
Chagas disease, or American trypanosomiasis, is a vector-borne parasitic infection caused by Trypanosoma cruzi, a flagellated protozoan (kinetoplastid) of the family Trypanosomatidae. The disease is endemic in Latin America, although cases are increasingly reported worldwide due to human migration. Transmission most commonly occurs when feces of infected triatomine bugs contaminate bite wounds or mucosal surfaces; additional routes include congenital, transfusional, transplant-related, and oral...