Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Augmented trabeculectomy in paediatric glaucoma.

R Ehrlich1, M Snir, M Lusky

  • 1Department of Ophthalmology, Rabin Medical Center, Beilinson Campus, Petah Tiqva 49 100, Israel. ehrlichy@netvision.net.il

The British Journal of Ophthalmology
|January 25, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Colorectal cancer T stage, size at diagnosis, and presentation 2017 to 2023: an analysis using Veterans Affairs data.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract·2026
Same author

An experimental investigation of light emission produced in the process of positronium formation in matter.

Physical chemistry chemical physics : PCCP·2021
Same author

Vaccinia-based oncolytic immunotherapy Pexastimogene Devacirepvec in patients with advanced hepatocellular carcinoma after sorafenib failure: a randomized multicenter Phase IIb trial (TRAVERSE).

Oncoimmunology·2019
Same author

Immunogenicity of oncolytic vaccinia viruses JX-GFP and TG6002 in a human melanoma in vitro model: studying immunogenic cell death, dendritic cell maturation and interaction with cytotoxic T lymphocytes.

OncoTargets and therapy·2017
Same author

Childhood overweight or obesity increases the risk of IIH recurrence fivefold.

International journal of obesity (2005)·2014
Same author

Contralateral lateral rectus muscle recession in patients with Duane retraction syndrome type 3.

Eye (London, England)·2013

Augmented trabeculectomy using mitomycin C and 5-fluorouracil effectively lowered intraocular pressure in pediatric glaucoma patients. This surgical approach shows promise as a primary treatment for selected young individuals with glaucoma.

Area of Science:

  • Ophthalmology
  • Surgical Innovation
  • Pediatric Glaucoma Management

Background:

  • Pediatric glaucoma presents unique management challenges.
  • Trabeculectomy is a common glaucoma surgery, but augmentation may improve outcomes.
  • Mitomycin C and 5-fluorouracil are antimetabolites used to enhance surgical success.

Purpose of the Study:

  • To evaluate the efficacy and safety of trabeculectomy augmented with mitomycin C and 5-fluorouracil in treating pediatric glaucoma.
  • To assess the impact on intraocular pressure, visual acuity, and optic nerve status.
  • To determine the long-term success rates and complication profile of this combined surgical approach.

Main Methods:

  • A retrospective, interventional case series was conducted.

Related Experiment Videos

  • Seventeen children (29 eyes) with primary or secondary glaucoma underwent augmented trabeculectomy.
  • Data collected included preoperative/postoperative intraocular pressure, visual acuity, optic disc status, and complications.

    • Main Results:

    • Intraocular pressure significantly decreased from a mean of 33.1 mmHg to 17.1 mmHg (p <0.0001).
    • Successful intraocular pressure control (<20 mmHg) was achieved in 75.8% of eyes, with a 3-year success rate of 86%.
    • Complications were infrequent, including retinal detachment, choroidal detachment, and blebitis in isolated cases.

    Conclusions:

    • Augmented trabeculectomy with mitomycin C and 5-fluorouracil is a viable primary surgical option for select pediatric glaucoma patients.
    • The procedure demonstrated significant intraocular pressure reduction and acceptable safety profile.
    • Further research may refine patient selection for optimal outcomes.