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Declining melatonin levels and older people. How old is old?
Deborah Graham1, Angus McLachlan
1School of Psychology, James Cook University, Cairns, Queensland, Australia. Deborah.Graham@jcu.edu.au
Objectives:
The purpose of this study was to investigate whether melatonin levels in older cohorts within the 'aged' population were significantly lower than in younger 'aged' individuals and hence point to a possible confound in cross-sectional studies which group individuals over 55 in one category.
Setting And Design:
Melatonin levels of 35 North Queensland residents over 55 years of age living in an aged-care facility, a retirement village or the general community were compared across three age groups.
Methods:
Subjects were ten 56-65 year olds, eighteen 66-75 year olds and seven over-75 year olds. Information was obtained on sleep, awakening, medical conditions and medications, with subsequent exclusion of those with known medical conditions and/or medications. Melatonin was collected by salivary samples at 2200 hours and concentrations were determined by immunoassay.
Results:
Mean melatonin levels were significantly lower (p=.03) in the 'oldest' (over 75 yrs) group compared to the 'youngest' (56-65 yrs) group.
Main Findings:
The results of this preliminary study indicate that within the older population, melatonin levels appear to decline significantly with age.
Conclusions:
Future studies of melatonin and ageing may benefit from a longitudinal approach, with older subjects sampled across time.
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