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Related Experiment Videos

Gold salt-induced cholestasis.

D Pessayre, G Feldmann, C Degott

    Digestion
    |January 1, 1979
    PubMed
    Summary
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    Transient intrahepatic cholestasis occurred in a patient receiving gold salt therapy. This gold salt adverse event also included skin and blood reactions, indicating potential intolerance.

    Area of Science:

    • Hepatology
    • Toxicology
    • Dermatology

    Background:

    • Gold salts are used in treating certain autoimmune conditions.
    • Adverse drug reactions to gold salts can affect multiple organ systems.

    Observation:

    • A patient developed transient intrahepatic cholestasis after receiving sodium aurothiopropanol sulfonate.
    • The patient also exhibited exfoliative dermatitis and eosinophilia.

    Findings:

    • Sodium aurothiopropanol sulfonate, a soluble gold salt, can cause intrahepatic cholestasis.
    • Gold salt intolerance may manifest as cholestatic liver injury, dermatitis, and eosinophilia.

    Implications:

    • Clinicians should monitor liver function in patients treated with gold salts.

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  • Recognizing these diverse adverse effects is crucial for patient safety and management.
  • This case highlights the spectrum of potential toxicities associated with gold salt therapy.