Related Experiment Video
Updated: Aug 19, 2026
Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
Published on: March 14, 2025
Brain SPECT imaging in children and adolescents with obsessive-compulsive disorder
A R G L Castillo1, C A Buchpiguel, L A S B de Araújo
1Division of Child and Adolescent Psychiatry, Department of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil. castillo@uol.com.br
Objective:
To evaluate the patterns of regional cerebral blood flow (rCBF) in cortical and subcortical regions by Brain SPECT imaging, in children and adolescents with obsessive-compulsive disorder (OCD) before and after treatment.
Method:
Fourteen OCD patients (6 to 17 years old) underwent brain SPECT; ten of those subjects were reexamined after successful treatment. rCBF ratios were correlated with clinical parameters on the 14 patients in symptomatic state, and we compared rCBF ratios of the ten patients before and after treatment.
Results:
There was no statistically significant difference in average ratios of rCBF before and after treatment. There were significant clinical correlations between current age and age of onset of OCD and rCBF in the bilateral superior frontal, and bilateral parietal cortical regions.
Conclusions:
Further investigations on abnormal neurodevelopment of cortical-subcortical circuits possibly involved in symptomatology of paediatric OCD are warranted.
