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Updated: Aug 19, 2026

A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs
Published on: February 18, 2022
Fatal inflammatory heart disease in a bonobo (Pan paniscus)
Peter Jones1, Crispin Mahamba, Joan Rest
1SMUR, l'Hôpital Robert Debré, 48 Boulevard Sérurier, 75019 Paris, France. petejones@caramail.com
Abstract:
We report the first probable identification of encephalomyocarditis virus (EMCV) in a bonobo (Pan paniscus) that had been part of a forest re-introduction programme. Clinical presentation was of episodic acute on chronic heart failure and cerebral infarction with end-stage renal failure rather than sudden death which is more commonly associated with EMCV infection. A postmortem diagnosis of probable EMCV was made using gross pathological and histopathological examination. Findings included acute on chronic heart failure combined with the unusual but characteristic histopathological features of non-suppurative necrotizing myocarditis with mononuclear, inflammatory infiltration of the brain.
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