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Related Experiment Videos

DPP10 modulates Kv4-mediated A-type potassium channels.

Edward Zagha1, Andres Ozaita, Su Ying Chang

  • 1Department of Physiology and Neuroscience, New York University School of Medicine, New York, New York 10016.

The Journal of Biological Chemistry
|January 27, 2005
PubMed
Summary

Dipeptidyl peptidase 10 (DPP10) protein modulates Kv4.2 potassium channels, impacting A-type currents in the central nervous system. This finding reveals DPP10

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Biochemistry

Background:

  • Dipeptidyl peptidase 10 (DPP10) is a newly identified protein family member structurally similar to dipeptidyl peptidase (DPP) IV.
  • DPP10 has been linked to asthma susceptibility, but its cellular functions remain unknown.
  • DPP10 is highly homologous to DPPX, a known modulator of Kv4-mediated A-type potassium channels.

Purpose of the Study:

  • To investigate the ability of DPP10 to modulate Kv4.2 channel properties in heterologous expression systems.
  • To determine the role of DPP10 in the central nervous system's A-type potassium currents.

Main Methods:

  • Heterologous expression systems were used to study DPP10's effect on Kv4.2 channels.
  • In situ hybridization was employed to examine DPP10 expression in brain tissues.

Related Experiment Videos

  • Immunoprecipitation was performed to detect DPP10 association with native Kv4.2 channels.
  • Chimera constructs of DPPX, DPP10, and DPPIV were created to identify functional domains.

    • Main Results:

    • DPP10 significantly modulated Kv4.2 channels, exhibiting activity similar to DPPX and distinct from DPPIV.
    • DPP10 facilitated Kv4.2 trafficking to the cell membrane, increased A-type current magnitude, and altered current kinetics.
    • DPP10 is prominently expressed in brain neuronal populations co-expressing Kv4 subunits and associates with native Kv4.2 channels.
    • Intracellular and transmembrane domains of DPPX and DPP10, but not DPPIV, are crucial for Kv4.2 channel modulation.

    Conclusions:

    • DPP10 functions as a modulator of Kv4.2 channels, influencing A-type currents in the central nervous system.
    • DPP10 is an integral component of native A-type potassium currents in the brain.
    • The intracellular and transmembrane domains of DPP10 are critical for its interaction with Kv4.2 channels.