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Development of implantable right ventricular assist device
Kojiro Furukawa1, Tadashi Motomura, Atsushi Hata
1Michael E. DeBakey Department of Surgery, Division of Transplant Surgery and Assist Devices, Center for Artificial Organ Development, Baylor College of Medicine, Houston, Texas, USA.
ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|January 28, 2005
Summary
Researchers explored an implantable right ventricular assist device (RVAD) using the PI-710 pump. This novel RVAD shows promise in animal models for treating right ventricular failure after left ventricular assist device implantation.
Area of Science:
- Cardiovascular Surgery
- Biomedical Engineering
- Medical Devices
Background:
- Right ventricular failure (RVF) is a significant complication post-left ventricular assist device (LVAD) implantation, affecting ~20% of patients.
- Current prediction of RVF is difficult, leading to high mortality rates.
- No implantable right ventricular assist device (RVAD) is currently available for clinical use.
Purpose of the Study:
- To investigate the feasibility of an implantable RVAD using the Gyro centrifugal pump (PI-710).
- To evaluate the performance and safety of the PI-710 pump as an RVAD in chronic animal experiments.
Main Methods:
- Eleven chronic animal experiments involving LVAD and RVAD implantation were conducted.
- A right heart bypass was created, and the PI-710 pump was implanted in the preperitoneal space.
- Pump performance, hemodynamic stability, and respiratory function were monitored throughout the experiments.
Main Results:
- The PI-710 pump demonstrated good anatomic fit and excellent performance in all experiments.
- Stable pulmonary hemodynamics and respiratory function were maintained for an average of 59 days.
- No significant abnormal lung histology was observed, though some cases showed tunica media hypertrophy.
Conclusions:
- The PI-710 pump is a feasible option for a clinically implantable RVAD.
- Further research is required to investigate long-term histologic and pulmonary vascular changes associated with RVAD implantation.