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Effect of antagonists vs agonists on in vitro fertilization outcome
M L Check1, J H Check, J K Choel
1The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Cooper Hospital/University Medical Center, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Camden, NJ, USA.
Purpose:
To compare outcome following in vitro fertilization-embryo transfer (IVF-ET) using controlled ovarian hyperstimulation (COH) regimens using either the gonadotropin-releasing hormone (GnRH) agonist leuprolide acetate vs the GnRH antagonist ganirelix.
Methods:
Women needing IVF for conception were randomly assigned to 300 IU of gonadotropins with ganirelix used in the follicular phase when a follicle with a 14 mm average diameter was attained vs a regimen using leuprolide acetate from the mid-luteal phase of the previous cycle.
Results:
There were no differences found in clinical, ongoing, delivered pregnancy rates or implantation rates between groups.
Conclusions:
The use of GnRH antagonists do not seem to reduce IVF outcome compared to using GnRH agonists in COH regimens.
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