Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Systemic sclerosis (scleroderma) and malignancy].

Seiji Takeda1

  • 1Division of Nephrology & Rheumatology, Department of Internal Medicine, Fukuoka University.

Nihon Rinsho Men'Eki Gakkai Kaishi = Japanese Journal of Clinical Immunology
|February 1, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Regional distribution and isotope ratios of radiocesium from the Fukushima Daiichi nuclear power station and global fallout in Tokai-mura.

Scientific reports·2025
Same author

Morphological and Transcriptome Analysis of the Near-Threatened Orchid <i>Habenaria radiata</i> with Petals Shaped Like a Flying White Bird.

Plants (Basel, Switzerland)·2025
Same author

Exploring the diversity of galls on <i>Artemisia indica</i> induced by <i>Rhopalomyia</i> species through morphological and transcriptome analyses.

Plant direct·2024
Same author

Relationships of the Surface Charge of Low-Density Lipoprotein (LDL) with the Serum LDL-Cholesterol and Atherosclerosis Levels in a Japanese Population: The DOSANCO Health Study.

Journal of atherosclerosis and thrombosis·2024
Same author

Gene-flow investigation between garden and wild roses planted in close distance.

Plant biotechnology (Tokyo, Japan)·2024
Same author

Binding properties of recombinant LDL receptor and LOX-1 receptor to LDL measured using bio-layer interferometry and atomic force microscopy.

Biophysical chemistry·2023
Same journal

[A case of mixed connective tissue disease positive for proteinase 3 antineutrophil cytoplasmic antibody in a patient with slowly progressive type 1 diabetes mellitus and chronic thyroiditis].

Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology·2018
Same journal

[A case of axial spondyloarthritis acute onset as opportunity tonsil foci infection].

Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology·2018
Same journal

[Transient detection of lupus anticoagulant in acute phase of Kawasaki disease].

Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology·2018
Same journal

[A case of anti-PL-7 antibody positive polymyositis with thrombotic microangiopathy].

Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology·2018
Same journal

[Autoimmune diseases and ubiquitin system].

Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology·2018
Same journal

[The scoring system for the risk-stratification in patients with the antiphospholipid syndrome].

Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology·2018
See all related articles

This review highlights the link between Systemic Sclerosis (SSc) and cancer, noting specific patient groups and potential mechanisms like fibrosis and immune dysfunction. Early detection is key for these malignancy risks.

Area of Science:

  • Rheumatology
  • Oncology
  • Immunology

Context:

  • The association between collagen diseases and malignancy is well-established, particularly dermatomyositis.
  • Systemic Sclerosis (SSc) shares a recognized link with various cancers.
  • Understanding this relationship is crucial for patient management and early detection.

Purpose:

  • To review the literature on the coexistence of Systemic Sclerosis (SSc) and malignancy.
  • To identify key characteristics of SSc patients at higher risk for cancer.
  • To explore the underlying mechanisms linking SSc and cancer development.

Summary:

  • The review identifies specific SSc patient profiles at increased cancer risk: late-onset, advanced skin sclerosis (Barnett III type), and male patients.

Related Experiment Videos

  • Three primary mechanisms are proposed: organ fibrosis predisposing to cancer (e.g., lung fibrosis and lung cancer), paraneoplastic syndromes, and SSc-related immunological derangements potentially causing carcinogenesis.
  • A notably short interval between SSc and breast cancer onset is observed. Longstanding reflux esophagitis and Barrett's esophagus in SSc patients may predispose to esophageal carcinoma.

    • Impact:

    • This review emphasizes the need for heightened vigilance regarding malignancy in specific SSc patient cohorts.
    • It provides insights into potential etiological pathways, guiding further research into SSc-associated carcinogenesis.
    • The findings can inform clinical practice, promoting earlier cancer screening and diagnosis in at-risk SSc patients.