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An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
Published on: December 11, 2013
The pediatric patient and upper respiratory infections
1Department of Anesthesiology and Pain Medicine, Children's Hospital and Regional Medical Center, Seattle, WA 98105-0317, USA. tomelwood@hotmail.com
Insights
Children with active upper respiratory infections undergoing elective surgery face increased risks. Clinician decisions on cancelling surgery vary, highlighting the need for standardized risk assessment and further research into managing respiratory illness during pediatric surgery.
Area of Science:
- Pediatric Anesthesiology
- Respiratory Medicine
- Surgical Risk Assessment
Background:
- Children often require elective surgery with active or recent upper respiratory infections (URIs).
- Increased respiratory adverse events are noted in this patient population.
- Current thresholds for surgical cancellation due to URIs lack clinical consistency.
Purpose of the Study:
- To review factors influencing decisions to proceed with or cancel elective surgery in children with URIs.
- To identify areas where more data are needed regarding surgical risks and management strategies.
- To explore potential therapies for reducing adverse events in this setting.
Main Methods:
- Literature review and clinical consensus discussion on risk factors.
- Analysis of variables such as respiratory secretions, pulmonary disease, intubation needs, and surgical site.
- Identification of knowledge gaps concerning perioperative outcomes.
Main Results:
- Surgical cancellation decisions are influenced by URI severity, patient comorbidities, airway management needs, and surgical location.
- Significant variability exists among clinicians regarding acceptable risk thresholds.
- Limited data exist on the precise risks of proceeding with surgery and the efficacy of interventions.
Conclusions:
- Standardized guidelines are needed for managing pediatric elective surgery in the context of URIs.
- Further research is crucial to quantify risks and evaluate therapies like lidocaine for managing laryngospasm in affected children.
Abstract:
Children frequently present for elective surgery in the setting of an active or recent upper respiratory infection. Respiratory adverse events are increased in this setting, but the threshold for cancelling a case varies widely between clinicians. A decision to cancel surgery should take into consideration the amount of respiratory secretions during the acute illness, coexisting pulmonary disease, the requirement for intubation, and the surgical site (airway, thorax, upper abdomen-each with their potential for complications). More data are needed on the risks of proceeding with surgery in the presence of these factors and on the impact of potential therapies to decrease the incidence of adverse events. Lidocaine and other therapies that reduce laryngospasm in well patients need to be evaluated in children with upper respiratory infection.
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