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Updated: Aug 9, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
[Cisplatin and derivatives with radiation therapy: for what clinical use?]
1Service d'oncologie-radiothérapie, hôpital européen Georges-Pompidou, AP-HP, HEGP, 20 rue Leblanc, 75015 Paris, France. catherine.maulard-durdux@hop.egp.ap-hop-paris.fr
Abstract:
Since its discovery by Rosenberg in 1965, cisplatin and its derivatives have appeared as the most important chemotherapeutic agents, particularly for their radiosensitizing properties and their clinical use with radiation. In spite of numerous preclinical and clinical studies, optimal schedules of platin and radiotherapy combination have to be defined. The first part of this overview will describe biological mechanisms of interaction between radiation therapy and platinum derivatives. The second part will report the major clinical impact of their association.
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