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Updated: Aug 19, 2026

Competitive Genomic Screens of Barcoded Yeast Libraries
Published on: August 11, 2011
A bunch of fun-guys: the whole-genome view of yeast evolution
Howard Ochman1, Vincent Daubin, Emmanuelle Lerat
1Department of Biochemistry and Molecular Biophysics, University of Arizona, Tucson, AZ 87521, USA. hochman@email.arizona.edu
Abstract:
The resolution of the complete sequences of several hemiascomycete genomes provides new insights into the ways that yeast genomes change in size and in gene contents. These genomes provide evidence of whole-genome duplication occurring before the divergence of Saccharomyces cerevisiae and Candida glabrata, followed by massive gene loss that restored diploidy. The pattern of genome evolution in yeast differs from that in bacteria apparently as a result of stronger selective constraints on bacterial chromosomes.
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