Related Experiment Videos
96-Well solid-phase extraction: a brief history of its development
Richard F Venn1, James Merson, Susan Cole
1Department of Pharmacokinetics, Dynamics and Metabolism (PDM), Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent CT139NJ, UK. dick@the-venns.demon.co.uk
Summary
The invention of the 96-well solid-phase extraction system revolutionized high-throughput bioanalysis. This adaptable technology is now a global standard for pharmaceutical analysis.
Area of Science:
- Analytical Chemistry
- Pharmaceutical Science
Background:
- The need for efficient sample preparation in bioanalysis.
- Limitations of existing methods for high-throughput screening.
Purpose of the Study:
- To describe the invention and development of the first 96-well solid-phase extraction system.
- To detail its adaptation for bioanalysis of pharmaceutical compounds.
- To discuss factors enabling increased productivity.
Main Methods:
- Development of a novel 96-well solid-phase extraction (SPE) system.
- Adaptation of the SPE system for bioanalytical applications.
- Analysis of factors contributing to enhanced throughput.
Main Results:
- The 96-well SPE system became a worldwide standard for high-throughput bioanalysis.
- The system's adaptability led to extensions like 384-well formats and other extraction techniques.
- Identified key factors driving productivity gains in bioanalysis.
Conclusions:
- The 96-well SPE system represents a significant advancement in bioanalytical sample preparation.
- Its widespread adoption underscores its impact on pharmaceutical research and development.
- The system's modularity and adaptability have facilitated further innovation in extraction technologies.