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Gamma-delta T cells as orally induced suppressor cells in rats: in vitro characterization

Gerhild Wildner1, Stephan R Thurau, Maria Diedrichs-Möhring

  • 1Section of Immunobiology, Department of Ophthalmology, Ludwig-Maximilians-University, Mathildenstr. 8, 80336 Munich, Germany. Gerhild.Wildner@med.uni-muenchen.de

Annals of the New York Academy of Sciences
|February 1, 2005
PubMed

Gamma-delta T cells from orally tolerized rats adoptively transfer suppression of experimental autoimmune uveitis. In vivo and in vitro these regulatory cells specifically recognize retinal autoantigen peptide PDSAg and its mimotope B27PD, but not other mimicry peptides. Proliferation of gamma/delta T cells was MHC class II and CD8 dependent.

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