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Resveratrol derivatives from Upuna borneensis
Tetsuro Ito1, Miyuki Furusawa, Toshiyuki Tanaka
1Gifu Prefectural Institute of Health and Environmental Sciences, Kakmigahara, Japan. zvn00510@nifty.com
Chemical & Pharmaceutical Bulletin
|February 3, 2005
Summary
Researchers discovered four novel resveratrol derivatives, upunaphenols B-E, from the Upuna borneensis plant stem. These compounds, including a resveratrol tetramer and dimer, expand the known family of resveratrol oligomers.
Area of Science:
- Natural Product Chemistry
- Phytochemistry
- Organic Chemistry
Background:
- Resveratrol and its oligomers are known for diverse biological activities.
- The Upuna borneensis plant, belonging to the Dipterocarpaceae family, is a potential source of novel bioactive compounds.
Purpose of the Study:
- To isolate and characterize new resveratrol derivatives from Upuna borneensis.
- To expand the understanding of resveratrol oligomer diversity in natural sources.
Main Methods:
- Extraction of acetone-soluble components from Upuna borneensis stem.
- Isolation of compounds using chromatographic techniques.
- Structure elucidation of new compounds via 1D and 2D Nuclear Magnetic Resonance (NMR) spectroscopy.
Main Results:
- Four new resveratrol derivatives, named upunaphenols B (1), C (4), D (5) (a resveratrol tetramer), and E (6) (a resveratrol dimer with a C6-C1 unit), were identified.
- Nine known resveratrol oligomers and resveratrol itself were also isolated.
- The structures were confirmed through comprehensive spectral analysis.
Conclusions:
- The study successfully identified novel resveratrol derivatives from Upuna borneensis.
- This discovery contributes to the known repertoire of resveratrol oligomers and their natural occurrence.