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Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16
Published on: July 15, 2019
Structural elucidation and virucidal properties of resveratrol octamers isolated from Vatica albiramis
Tetsuro Ito1, Masashi Fukaya2, Ryuichi Sawa3
1Laboratory of Pharmacognosy, Faculty of Pharmacy, Gifu University of Medical Science, 4-3-3 Nijigaoka, Kani, Gifu, 509-0293, Japan. tito@u-gifu-ms.ac.jp.
Abstract:
Two highly condensed resveratrol octamers, vateriaphenol A and a newly discovered analogue, vaticanol Q, were isolated from the stem of Vatica albiramis. Vaticanol Q represents the first naturally occurring resveratrol octamer bearing a rare ortho-quinone moiety, as unambiguously established through comprehensive spectroscopic analyses, including low-temperature NMR and circular dichroism. The absolute configuration of vaticanol Q was deduced based on biosynthetic considerations and chiroptical data, further supported by micro-electron diffraction and synchrotron X-ray crystallography of its biosynthetic precursor, (-)-hopeaphenol. Vateriaphenol A exhibited potent virucidal activities against feline calicivirus, influenza A virus, and mumps virus, highlighting the potential of highly condensed stilbenoids as promising antiviral leads.
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