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Ketamine-medetomidine anesthesia with atipamezole reversal: practical anesthesia for rodents under field conditions

Nina Hahn1, Rebecca J Eisen, Lars Eisen

  • 1Office of Laboratory Animal Care, University of California, Berkeley, Berkeley, CA, USA. nhahn@olac.berkeley.edu

Lab Animal
|February 3, 2005
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Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.