Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

IGFBPs and breast cancer.

Claire M Perks1, Jeff M P Holly

  • 1Division of Surgery, Department of Hospital Medicine, Level 7, Bristol Royal Infirmary, Bristol, BS2 8HW, UK. Claire.M.Perks@bris.ac.uk

Breast Disease
|February 3, 2005
PubMed
Summary

Insulin-like growth factor-binding proteins (IGFBPs) regulate insulin-like growth factors (IGFs) in breast tissue. Dysregulation of the IGF system can disrupt local tissue balance.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A feasibility randomised controlled trial of water-only fasting prior to CAPOX chemotherapy for stage 2/3 colorectal cancer.

Pilot and feasibility studies·2026
Same author

Unravelling the effects of selective estrogen receptor modulators on colorectal cancer: a prognostic role for insulin-like growth factor binding protein-5.

Clinical science (London, England : 1979)·2026
Same author

Correction: Intrinsic, pro-apoptotic effects of IGFBP-3 on breast cancer cells are reversible: involvement of PKA, Rho, and ceramide.

Frontiers in endocrinology·2026
Same author

Does childhood obesity foreshadow a future time-bomb of early and more aggressive cancers?

Frontiers in endocrinology·2026
Same author

Androgen Effects on Amyloid Precursor Protein Processing Pathways in Cancer: A Systematic Review.

Current issues in molecular biology·2026
Same author

Correction: Kingshott et al. Alteration of Metabolic Conditions Impacts the Regulation of IGF-II/H19 Imprinting Status in Prostate Cancer. <i>Cancers</i> 2021, <i>13</i>, 825.

Cancers·2026

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Oncology

Background:

  • The Insulin-like Growth Factor Binding Protein (IGFBP) family includes six high-affinity proteins for Insulin-like Growth Factors (IGFs).
  • IGFBP production in breast tissue is influenced by hormones, local regulators, and estrogen receptor status in tumors.
  • Post-translational modifications like proteolysis, phosphorylation, and glycosylation impact IGFBP functional activity.

Purpose of the Study:

  • To elucidate the regulatory roles of IGFBPs in breast tissue homeostasis.
  • To understand the influence of IGF system components on local IGF bioactivity.
  • To explore the implications of IGF system imbalance in breast tissue.

Main Methods:

  • Review of existing literature on IGFBP family, IGFs, and their interactions.
  • Analysis of regulatory mechanisms controlling IGFBP production and function.
  • Examination of the interplay between local and systemic factors affecting IGF bioactivity.

Main Results:

  • IGFBPs are critical regulators of IGF cellular actions, modulating their activity in both IGF-dependent and independent ways.
  • Local IGF bioactivity in the breast is a complex interplay of tissue-expressed IGFs, IGFBPs, proteases, and circulating factors.
  • Estrogen receptor status is relevant to IGFBP regulation in breast tumors.

Conclusions:

  • The balance of the IGF system, including IGFs and IGFBPs, is crucial for maintaining breast tissue homeostasis.
  • Disruptions in the IGF system can lead to pathological conditions.
  • Further research into IGFBP regulation and function is warranted for understanding breast health and disease.

Related Experiment Videos