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Processing of Bronchoalveolar Lavage Fluid and Matched Blood for Alveolar Macrophage and CD4+ T-cell Immunophenotyping and HIV Reservoir Assessment
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[Pulmonary alveolar proteinosis in AIDS patients]

Alina Floarea-Strat1, Adriana Grigoraş, Gioconda Dobrescu

  • 1Spitalul Clinic de Boli Infecţioase Iaşi, Universitatea de Medicină şi Farmacie Gr.T. Popa Iaşi, Facultatea de Medicina.

Revista Medico-Chirurgicala a Societatii De Medici Si Naturalisti Din Iasi
|February 4, 2005
PubMed

Insights

Pulmonary alveolar proteinosis in patients with Acquired Immunodeficiency Syndrome (AIDS) presents as lung consolidation. Microscopic analysis revealed a granular, PAS-positive material filling the alveoli.

Area of Science:

  • Pulmonology
  • Pathology
  • Infectious Diseases

Context:

  • Pulmonary alveolar proteinosis (PAP) is a rare lung disease.
  • Acquired Immunodeficiency Syndrome (AIDS) can predispose individuals to opportunistic infections and other complications.
  • This study examines PAP in the context of AIDS.

Purpose:

  • To describe the pathological findings of pulmonary alveolar proteinosis in patients with AIDS.

Summary:

  • Four patients with AIDS who died from pulmonary alveolar proteinosis were studied.
  • Autopsy revealed macroscopic yellow-gray nodular consolidation in the lungs.
  • Microscopic examination showed alveoli filled with a granular, acidophilic, Periodic Acid Schiff (PAS)-positive material.

Impact:

  • Highlights the characteristic histopathological features of PAP in AIDS patients.
  • Contributes to the understanding of rare pulmonary manifestations in immunocompromised individuals.
  • Informs diagnostic approaches for similar cases.

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