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Angiogenesis: a link to thrombosis in athero-thrombotic disease

Edward M Conway1

  • 1Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Belgium. ed.conway@med.kuleuven.ac.be

Pathophysiology of Haemostasis and Thrombosis
|February 5, 2005
PubMed

Insights

Atherosclerosis leads to thrombosis, causing heart attacks and strokes. Angiogenesis, or new blood vessel growth, in plaques promotes this, presenting a challenge for treatment despite efforts to improve vascular function.

Area of Science:

  • Cardiovascular Research
  • Vascular Biology
  • Thrombosis and Hemostasis

Background:

  • Atherosclerosis is understood to cause acute coronary syndromes, peripheral artery disease, and stroke primarily through thrombosis.
  • Current therapeutic strategies focus on inhibiting thrombin and fibrin formation to manage atherothrombotic events.

Purpose of the Study:

  • To explore the role of angiogenesis in the development and progression of atherothrombosis.
  • To understand the clinical implications of plaque angiogenesis in the context of existing treatment paradigms.

Main Methods:

  • Review of recent studies investigating the relationship between angiogenesis and atherothrombosis.
  • Analysis of the challenges in treating atherothrombotic disease given new insights into plaque biology.

Main Results:

  • Recent findings highlight angiogenesis of the atherosclerotic plaque as a key factor promoting atherothrombosis.
  • This contrasts with therapeutic efforts aimed at enhancing vascular function using angiogenic agents.

Conclusions:

  • Angiogenesis within atherosclerotic plaques plays a critical role in atherothrombosis.
  • The dual role of angiogenesis presents a significant therapeutic challenge in managing cardiovascular diseases like heart attack and stroke.

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