Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The propionic acids: a personal perspective.

S S Adams1

  • 1Research Department, Boots Co., Nottingham, England.

Journal of Clinical Pharmacology
|April 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fear of childbirth and duration of labour: a study of 2206 women with intended vaginal delivery.

BJOG : an international journal of obstetrics and gynaecology·2012
Same author

Mode of delivery and postpartum emotional distress: a cohort study of 55,814 women.

BJOG : an international journal of obstetrics and gynaecology·2011
Same author

Fevers in children; their significance, general diagnostic value and antipyretic treatment.

Archives of pediatrics·2010
Same author

Ibuprofen, the propionics and NSAIDs: personal reflections over four decades.

Inflammopharmacology·2007
Same author

Comprehensive follow-up care and life-threatening illnesses among high-risk infants: A randomized controlled trial.

JAMA·2000
Same author

The Titanic is not the best analogy for enoxaparin.

Anesthesia and analgesia·1999
Same journal

Human Disposition, Metabolism, and Excretion of Sevasemten (EDG-5506), a Selective Modulator of Fast Myosin in Healthy Volunteers.

Journal of clinical pharmacology·2026
Same journal

New Insights into Genetic Polymorphisms Influencing the Therapeutic Efficacy and Toxicity of Rivaroxaban.

Journal of clinical pharmacology·2026
Same journal

Physiologically Based Pharmacokinetic Modeling to Predict the Pharmacokinetics of Sacubitril/Valsartan in the Elderly with Renal or Hepatic Impairment Population.

Journal of clinical pharmacology·2026
Same journal

The Journal of Clinical Pharmacology: 65 Years of History.

Journal of clinical pharmacology·2026
Same journal

Decoupling CAR-T Expansion, Conversion, and Decay Timing: Physiologically Aligned Semi-Mechanistic Modeling With Smooth Gating and a Cauchy Likelihood Residual Model.

Journal of clinical pharmacology·2026
Same journal

Mind the Gap: Unraveling the Pharmacokinetic Variability of Δ9-Tetrahydrocannabinol (THC).

Journal of clinical pharmacology·2026
See all related articles

The development of ibuprofen for rheumatoid arthritis involved testing various drug classes, ultimately leading to a safer and effective nonsteroidal anti-inflammatory drug (NSAID) option. Ibuprofen

Area of Science:

  • Pharmacology
  • Drug Discovery
  • Rheumatology

Background:

  • Limited understanding of drug mechanisms for rheumatoid arthritis in the 1950s.
  • Aspirin's analgesic action and anti-rheumatic effects were not well-defined.
  • Initial research explored ultraviolet (UV) erythema delay in guinea pigs as a model for drug activity.

Purpose of the Study:

  • To discover new drugs for rheumatoid arthritis treatment.
  • To identify compounds with both anti-rheumatic and analgesic properties.
  • To develop a safer alternative to existing treatments.

Main Methods:

  • Screening of substituted phenoxypropionic acids and phenylacetic acids.
  • Evaluation of anti-erythemic activity in guinea pigs.
  • Clinical trials for rheumatoid arthritis efficacy and adverse reactions (ADRs).

Related Experiment Videos

  • Iterative refinement of drug candidates based on laboratory and clinical data.

    • Main Results:

    • Substituted phenoxypropionic acids showed anti-erythemic activity but lacked clinical efficacy in rheumatoid arthritis.
    • Substituted phenylacetic acids were active but caused significant ADRs.
    • Substituted phenylpropionic acids, including ibuprofen, demonstrated a favorable balance of efficacy and tolerability.
    • Ibuprofen was launched in 1969 and later approved for over-the-counter (OTC) use due to its safety and effectiveness.

    Conclusions:

    • Ibuprofen emerged as a successful nonsteroidal anti-inflammatory drug (NSAID) from a systematic drug discovery process.
    • Its development highlights the importance of refining testing systems and considering therapeutic indices.
    • Ibuprofen offers a safer and effective option for rheumatoid arthritis and other painful conditions compared to aspirin or acetaminophen, especially in overdose.