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[Disulone].

E Begon1, O Chosidow, P Wolkenstein

  • 1Service de Dermatologie du Pr Revuz, Hôpital Henri Mondor, avenue du Maréchal de Lattre de Tassigny, 94000 Créteil. isadoud@libertysurf.fr

Annales De Dermatologie Et De Venereologie
|February 5, 2005
PubMed
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Dapsone (4,4'-diaminodiphenylsulfone, DDS) is a long-standing antibacterial and anti-inflammatory drug effective for various skin conditions involving neutrophil and eosinophil accumulation. This review clarifies its uses, mechanism, and side effects in dermatology.

Area of Science:

  • Dermatology
  • Pharmacology

Context:

  • Dapsone (4,4'-diaminodiphenylsulfone, DDS) has been utilized for six decades in treating dermatologic disorders.
  • Its efficacy is particularly noted in conditions with abnormal neutrophil and eosinophil accumulation.
  • Dermatitis herpetiformis is a well-recognized condition responding to dapsone.

Purpose:

  • To review current knowledge on dapsone's pharmacokinetics, mechanism of action, and side effects in dermatology.
  • To specify and classify pathological states where dapsone (also known as disulone) could be indicated, despite a lack of controlled studies.

Summary:

  • Dapsone exhibits both antibacterial and anti-inflammatory properties, making it valuable for diverse dermatologic conditions.
  • The drug's effectiveness varies across different inflammatory and bullous dermatoses.

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  • Understanding dapsone's pharmacokinetic profile, mechanism, and adverse effects is crucial for its appropriate application.

    • Impact:

    • Provides a consolidated overview of dapsone's role in dermatological treatment.
    • Aims to guide clinicians in identifying appropriate indications for dapsone therapy.
    • Highlights the need for further controlled studies to fully establish its therapeutic utility.