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Pneumococcal bacteraemia during a recent decade.

A Kuikka1, J Syrjänen, O V Renkonen

  • 1Second Department of Medicine, Helsinki University Central Hospital, Finland.

The Journal of Infection
|March 1, 1992
PubMed
Summary
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Bacteraemic pneumococcal infection fatality rates decreased from the 1970s to 1980s. Thrombocytopenia and circulatory acidosis were key predictors of fatal outcomes in adult patients.

Area of Science:

  • Infectious Diseases
  • Clinical Medicine
  • Epidemiology

Background:

  • Pneumococcal bacteremia poses a significant threat to adult health.
  • Understanding trends in underlying conditions and prognostic factors is crucial for improving patient outcomes.

Purpose of the Study:

  • To analyze changes in underlying diseases and prognostic factors for pneumococcal bacteremia.
  • To identify key predictors of mortality in adult patients.

Main Methods:

  • Retrospective review of 159 episodes of pneumococcal bacteremia in 157 adult patients.
  • Comparison of data from two distinct periods: 1976-1979 and 1986-1989.
  • Multivariate logistical regression analysis to identify independent predictors of mortality.

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Main Results:

  • Overall case fatality rate was 21%, with a trend towards reduction from 28% to 17% between the two periods.
  • Common underlying factors included alcohol abuse, cardiovascular diseases, and COPD.
  • Thrombocytopenia and circulatory acidosis were identified as the most significant independent predictors of fatal outcomes.

Conclusions:

  • A modest decrease in pneumococcal bacteremia mortality was observed.
  • Specific clinical and laboratory findings, particularly thrombocytopenia and circulatory acidosis, are critical for predicting fatal outcomes.
  • While old age was not a predictor, certain comorbidities significantly impacted mortality.