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The Achilles Functional Index.

G A Murrell1, E G Lilly, H Davies

  • 1Division of Orthopaedic Surgery, Duke University Medical Center, Durham, North Carolina 27710.

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
|May 1, 1992
PubMed
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Researchers developed a novel method to assess Achilles tendon function in rats using footprint analysis. This new Achilles Functional Index (AFI) provides a reliable way to study tendon injuries and healing.

Area of Science:

  • Biomedical Engineering
  • Orthopedic Research
  • Animal Models

Background:

  • Management of Achilles tendon rupture lacks consensus due to study limitations.
  • A validated animal model is crucial for advancing research and testing innovations.

Purpose of the Study:

  • To develop and validate a quantitative method for assessing Achilles tendon function in rats.
  • To establish an "Achilles Functional Index" (AFI) based on gait analysis.

Main Methods:

  • Measurements of hindpaw prints from walking rats were analyzed.
  • Four gait variables were quantified, and a proportional deficit was calculated.
  • Multiple linear regression analysis was used to create the AFI, weighting variables for functional deficit.

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Main Results:

  • A sham operation showed no functional deficit.
  • A 0.5-cm Achilles tendon defect resulted in a markedly impaired AFI.
  • Repaired transected tendons showed significant but less severe impairment, returning to baseline by day 15.
  • Excellent correlation (r=0.94) found between functional recovery and biomechanical properties.

Conclusions:

  • The developed rat model and AFI effectively quantify Achilles tendon function.
  • This model can differentiate between tendon defects and repairs, aiding in the study of healing.
  • The AFI correlates well with biomechanical healing, offering a valuable tool for orthopedic research.