Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hypodipsic hypernatraemia in a miniature schnauzer.

J Van Heerden1, J Geel, D J Moore

  • 1Department of Companion Animal Medicine and Surgery, Faculty of Veterinary Science, Medical University of Southern Africa, Medunsa.

Journal of the South African Veterinary Association
|March 1, 1992
PubMed
Summary

A Miniature Schnauzer with congenital primary hypodipsia experienced normovolaemic hypernatraemia due to a defective thirst mechanism. Controlled fluid intake successfully managed the condition, preventing neurological complications.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unraveling the intersection of aging and Parkinson's disease: a collaborative roadmap for advancing research models.

NPJ Parkinson's disease·2026
Same author

Barriers and Facilitators to PrEP Adherence among Transgender and Non-binary Individuals: A Mixed-Methods Analysis of Psychosocial Factors and Health Belief Model Constructs.

AIDS and behavior·2025
Same author

The impact of mild COVID-19 on medium-term respiratory function.

African journal of thoracic and critical care medicine·2024
Same author

The use of faecal microbiota transplant as treatment for recurrent or refractory Clostridioides difficile infection and other potential indications: second edition of joint British Society of Gastroenterology (BSG) and Healthcare Infection Society (HIS) guidelines.

The Journal of hospital infection·2024
Same author

The Association of Clinical Characteristics and Tumour Markers With Image-Defined Risk Factors in the Management of Neuroblastoma in South Africa.

Clinical oncology (Royal College of Radiologists (Great Britain))·2021
Same author

The Association between Tumour Markers and Meta-iodobenzylguanidine Scans in South African Children with High-risk Neuroblastoma.

Clinical oncology (Royal College of Radiologists (Great Britain))·2021

Area of Science:

  • Veterinary Medicine
  • Endocrinology
  • Nephrology

Background:

  • Congenital primary hypodipsia is a rare disorder characterized by a defective thirst mechanism.
  • Normovolaemic hypernatraemia, despite normal hydration status, presents a diagnostic challenge in veterinary medicine.

Observation:

  • A young male Miniature Schnauzer presented with chronic hypernatraemia (elevated serum sodium) but no signs of dehydration.
  • Despite elevated serum sodium, the dog exhibited a high urine osmolality: plasma osmolality ratio, ruling out antidiuretic hormone deficiency.
  • Hormonal assays for cortisol, thyroxine, aldosterone, and renin activity were within normal ranges.

Findings:

  • A defective central thirst regulation mechanism was diagnosed as the cause of primary hypodipsia.
  • Excessive voluntary water intake led to episodes of hyponatraemia (low serum sodium) and cerebral oedema.

Related Experiment Videos

  • A management plan involving calculated fluid intake based on daily maintenance requirements was implemented.

    • Implications:

    • This case highlights the importance of considering central thirst defects in cases of unexplained hypernatraemia in dogs.
    • Careful fluid management is crucial to prevent both hypernatraemia and iatrogenic hyponatraemia in affected animals.
    • Long-term monitoring and controlled fluid intake can lead to successful management and a good prognosis for dogs with primary hypodipsia.