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Serum homocysteine concentration in patients with acute MI and chronic IHD
1Dept. of Biochemistry, Shahabuddin Medical Collage, Gulsan, Dhaka.
Insights
Serum homocysteine (Hcy) levels are significantly elevated in patients with acute myocardial infarction (AMI) and chronic ischemic heart disease (CHD) in Bangladesh. These findings highlight Hcy as a potential biomarker for ischemic heart disease in the Bangladeshi population.
Area of Science:
- Biochemistry
- Cardiovascular Medicine
- Clinical Diagnostics
Background:
- Cardiovascular disease prevalence is rising in Bangladesh.
- Elevated serum homocysteine (Hcy) is linked to ischemic heart disease (IHD) in international studies.
- The association of Hcy with IHD in the Bangladeshi population requires investigation.
Observation:
- An observational study was conducted with 70 subjects: 20 with Acute Myocardial Infarction (AMI), 20 with Chronic Ischemic Heart Disease (CHD), and 30 healthy controls.
- Serum Hcy levels were quantitatively measured using fluorescence polarization immunoassay (FPIA).
- Mean Hcy levels were 21.16 ± 4.56 µmol/L for AMI, 27.55 ± 10.40 µmol/L for CHD, and 13.03 ± 10.51 µmol/L for controls.
Findings:
- Serum Hcy levels were significantly higher in both AMI and CHD patients compared to healthy controls (P<0.05).
- No significant difference in serum Hcy levels was observed between AMI and CHD groups (P>0.05).
Implications:
- Elevated serum Hcy is associated with acute and chronic ischemic heart disease in the Bangladeshi population.
- Serum Hcy may serve as a valuable biomarker for assessing ischemic heart disease risk and severity in Bangladesh.
- Further research could explore the clinical utility of Hcy testing for cardiovascular disease management in this region.
Abstract:
This was an observational study carried out in the Department of Biochemistry, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka; with the active co-operation of Coronary Care Unit (CCU) of BSMMU & National Institute of Cardiovascular Disease (NICVD), Dhaka. This study was carried out from March 2002 to January 2003. Total seventy (70) subjects were studied. Out of them 20 were of Acute MI, 20 were Chronic ischemic heart disease (CHD) and 30 were age and sex matched healthy controls. Hospitalized diagnosed patients were selected by taking history, clinical examination and several investigations like ECG. Echocardiogram, Angiogram and several enzymes assay. Several studies in many countries showed that serum homocysteine (Hcy) was elevated in IHD Patient. Cardiovascular disease is alarmingly increasing in Bangladesh. So our aim and objective of the study was to find out the association of serum Hcy with Acute MI and chronic ischemic heart disease (CHD) patients in our population. Mean Hcy level of Acute MI were 21.16 +/- 4.56 (micromol/l), 27.55 +/- 10.40 (micromol/l) and that of control was 13.03 +/- 10.51(micromol/l). Serum Hcy was significantly higher in both cases than control. But insignificant difference was found between AMI vs CHD (P> 0.05). Quantitative measurement of serum Hcy was measured by fluorescence polarization Immunoassay (FPIA) in IMX analyzer (Abbott-USA).
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