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Related Experiment Videos

Gastrointestinal citrate absorption in nephrolithiasis.

J Fegan1, R Khan, J Poindexter

  • 1Center for Mineral Metabolism and Clinical Research, University of Texas Southewestern Medical Center, Dallas 75235-8885.

The Journal of Urology
|May 1, 1992
PubMed
Summary

Gastrointestinal absorption of citrate is efficient in patients with kidney stones and low urinary citrate. This study suggests impaired citrate malabsorption is unlikely to cause hypocitraturia in these individuals.

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Area of Science:

  • Nephrology
  • Gastroenterology
  • Metabolic Disorders

Background:

  • Idiopathic hypocitraturia is a risk factor for calcium nephrolithiasis.
  • The cause of hypocitraturia in many stone formers remains unclear.

Purpose of the Study:

  • To investigate whether impaired gastrointestinal citrate absorption contributes to idiopathic hypocitraturia in kidney stone patients.

Main Methods:

  • Oral potassium citrate absorption was measured in 7 stone patients and 7 normal subjects using an intestinal washout technique.
  • Citrate recovery in intestinal lavage fluid quantified absorption efficiency.

Main Results:

  • Citrate absorption was rapid and efficient in both groups, with 96-98% absorbed within 3 hours.
Keywords:
NASA Discipline Regulatory PhysiologyNon-NASA Center

Related Experiment Videos

  • No significant differences were observed in serum citrate levels or absorption kinetics between stone patients and controls.
  • Absorption was slightly less efficient from a tablet formulation compared to a liquid preparation, but still high (91% vs. 98%).

    • Conclusions:

    • Impaired gastrointestinal citrate absorption is unlikely to be the primary cause of hypocitraturia in kidney stone patients without known bowel disease.
    • Urinary citrate levels are not solely dependent on gastrointestinal absorption efficiency.